Nano technology

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Nanoparticle Drug Delivery Systems

Medical Engineering Collaboration / Life SciencesNano technology

Nanoparticle Drug Delivery Systems

Brain cancer is most fatal among various types of cancer. Here, solid-lipid nanoparticles, which are formed by tiny pores, are successfully synthesised. Anti-cancer drugs are encapsulated in each pore and the surface of the particles are modified with transferrin and RGD tripeptide. The particles are monodisperse in water and biocompatible/biodegradable.
It has been proved by in vivo experiments that the drug encapsulated nanoparticles modified with transferrin and RGD penetrate the blood-brain barrier and reach brain tumours, as a result of which the target tumours are completely cured without showing any side effects. The optimal ratio of RGD to transferrin is obtained.
The present methodology can be applied to the treatment of different types of cancer by changing the surface modification and drugs.
Magnetic nanoparticles and quantum dots can be encapsulated in the present particles so that the particles can also be used for nano bio-imaging. The particles can be precisely manipulated by applying gradient dc magnetic fields, whereas they can be heated by applying high-frequency ac magnetic fields so that the drug release speed can be controlled and they can also be used for hyperthermia therapy.

MEMS infrared photodetector

ManufacturingNano technology

MEMS infrared photodetector

In Kan Laboratory at the University of Electro-Communications, we are conducting research on unique MEMS optical sensors and devices by fabricating micro- to nano-sized metal diffraction gratings and pillar structures on silicon. Normally, silicon alone does not have sensitivity to infrared light, but by utilizing the Schottky barrier formed at the interface between silicon and metal, it becomes possible to electrically detect infrared light with silicon. By absorbing externally incident light with diffraction gratings or pillar structures formed through MEMS processes, it is also possible to selectively detect specific wavelengths or polarizations of light. By utilizing these features, it is possible to construct infrared light detectors using silicon-based devices, as well as to develop spectroscopic sensors, gas sensors, and chemical sensors. Furthermore, by using silicon as the substrate material, it has the advantage of being able to utilize existing semiconductor manufacturing processes and leverage the legacy of semiconductors. This is a highly efficient method in terms of mass production and system integration. In this way, Kan Laboratory is utilizing unique MEMS principles to advance research on ultra-compact, cost-effective optical sensors with simplified manufacturing processes.

Ultra small spectrometer which is applicable to near-infrared region by using MEMS processes

Environment / Organic chemistry / Inorganic chemistryNano technology

Ultra small spectrometer which is applicable to near-infrared region by using MEMS processes

We are researching a small spectrometer using MEMS processes.
The wavelength band of the object depends on design, and can be spectroscopically divided into 20 nm resolution at the near-infrared range of 1200 nm to 1500 nm, for example.
We also examine spectroscopic methods in the visible light region and in the longer wavelength region. The size of the small-scale spectrometer has some good prospect of several mm of thickness and about 1 cm wide so that it can also be installed on portable devices such as smartphones. The features are the simple manufacturing process, the cost effective, and excellent portability. We welcome anyone who is interested in realizing its practical use and joint research of this technology.