AkaSuke™: A Highly bright luminescence substrate for in vivo bioluminescence imaging (BLI)

Shojiro Maki, University of Electro Communications – Nobuo Kitada, University of Electro Communications – Ryohei Moriya, Tokyo University of Pharmacy and Life Sciences – Hiroshi Aoyama, Tokyo University of Pharmacy and Life Sciences – Ryosuke Ijuin, Tokyo University of Pharmacy and Life Sciences

• Compared to D-luciferin, Akasuke enables high-sensitivity imaging with a small dosage and emits near-infrared wavelengths(680nm)that are highly permeable to biological tissues.
• Reacts with Fluc, a natural enzyme, to achieve high luminosity.
• High water solubility in buffer solution.

• High brightness by using natural enzyme “Fluc”. (No specialized enzymes required)
• Capable of emitting light at 680nm that enables measurement at deep bio tissues.
• Capable of analyzing areas with high blood flow, such as the brain and lungs

• Visualization of micro-cancer metastasis
• Observation of infectious disease kinetics]